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Updated: Apr 11, 2026

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
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Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

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両親を忘れて:ヒトの生殖細胞における表遺伝的再プログラム

Ferdinand von Meyenn1, Wolf Reik2

  • 1Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.

Cell
|June 6, 2015
PubMed
まとめ

人間の生殖細胞は,記憶を消し去り,潜在能力をリセットするために,エピジェネティック再プログラムを受けます. 研究は,原始生殖細胞におけるユニークな転写ネットワークとDNAメチル化による消去を明らかにしています.

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Methods of Nuclear Reprogramming01:24

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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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