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Updated: Apr 11, 2026

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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核孔複合体の中央チャネルをゲーティングするアロステリック規制

Junseock Koh1, Günter Blobel1

  • 1Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Cell
|June 6, 2015
PubMed
まとめ

この研究は,核毛孔複合体 (NPC) が輸送チャネルをダイナミックに変化させる方法を明らかにしています. 輸送因子と相互作用する内在的に無秩序な領域は,チャネルサイズを制御する構造ドメインをアロステリックに調節します.

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