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Updated: Apr 11, 2026

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
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Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

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独特の遺伝子規制ネットワークは,ヒトの生殖系統のエピジェノームを発達のためにリセットします

Walfred W C Tang1, Sabine Dietmann2, Naoko Irie1

  • 1Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 1QN, UK; Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 3EG, UK.

Cell
|June 6, 2015
PubMed
まとめ

人間の生殖系統のエピジェノームの再プログラミングは,DNA脱メチル化とクロマチンの変化を誘発する特定の遺伝子ネットワークによってユニークです. 一部の元素は脱メチル化に抵抗し,世代を超えた表遺伝子遺伝が発達や病気に影響を及ぼす可能性を示唆しています.

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