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Updated: Apr 11, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

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HDLに結合したスフィンゴシン-1-ホスファートはリンパポエシスと神経炎症を抑制する

Victoria A Blaho1, Sylvain Galvani2, Eric Engelbrecht2

  • 11] Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA [2] Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, New York 10065, USA.

Nature
|June 9, 2015
PubMed
まとめ

アポリポプロテインM-スフィンゴシン-1-ホスファート (ApoM-S1P) 複合体は,親細胞のS1P1受容体を活性化することによって,免疫細胞の生成を抑制します. この発見は,適応免疫と潜在的な治療標的を制御する新しいメカニズムを明らかにしています.

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