性別の決定. 性別の決定. foxl3は,メダカにおける精子・卵の運命決定に関与する生殖細胞内在的因子です
Toshiya Nishimura1, Tetsuya Sato2, Yasuhiro Yamamoto3
1Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan. Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan.
Science (New York, N.Y.)
|June 13, 2015
まとめ
foxl3遺伝子は,メダカ魚における精子・卵の運命を決定する上で極めて重要です. XXメダカにおける foxl3の破壊は,卵巣内の精子発育につながり,生殖細胞の内在的なシューを明らかにします.
科学分野:
- 生殖生物学 生殖生物学
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
背景:
- 精子または卵へのコミットメントは不可欠です.
- 脊椎動物の生殖細胞の性運命を左右する内在的要因は,ほとんど不明のままである.
- foxl3遺伝子は,性腺内の体細胞ではなく,生殖細胞で発現する.
研究 の 目的:
- メダカ魚における精子・卵の運命を決定する foxl3 の役割を調査する.
- 生殖細胞が性的な運命を決定するための内在的な要因を持っているかどうかを判断する.
- 女性の性腺環境での精子生成を調査する.
主な方法:
- 成人XXメダカの分析 障害の foxl3.1.
- 性腺の組織学的検査. 性腺の組織学的検査.
- チメリック・メダカ・モデルの作成と分析.
主要な成果:
- XXメダカにおける foxl3の障害は,卵巣内の有能な精子産生をもたらした.
- 変異性生殖細胞は,キメリックモデルにおける雌性野生型の性腺で精子生成を開始した.
- 精子生成は,女性の性腺環境の中で進行することが観察されました.
結論:
- foxl3遺伝子は,メダカ生殖細胞の固有の精子-卵の運命を決定する重要な役割を果たします.
- メダカの生殖細胞は,精子と卵の運命を決定するための内在的なヒントを持っています.
- 精子生成は,内在的な生殖細胞因子の影響を受け,女性の性腺環境で起こる可能性があります.
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