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Updated: Apr 10, 2026

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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細胞分裂サイクル. キネトコアにおけるMPS1とマイクロチューブル間の競争は,スパインドルのチェックポイントシグナリングを調節する

Yoshitaka Hiruma1, Carlos Sacristan2, Spyridon T Pachis2

  • 1Division of Biochemistry, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands. Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands. Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands.

Science (New York, N.Y.)
|June 13, 2015
PubMed
まとめ

スピンドルアセンブリチェックポイントタンパク質キナーゼMPS1は,NDC80複合体と相互作用し,染色体がマイクロチューブルに結合するまで細胞分裂を防ぐ. 微小管の結合は,この相互作用を妨害し,細胞分裂のための適切なスパインドル組織を確保します.

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