Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.9K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.9K
Interference and Decay01:16

Interference and Decay

581
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
581
Understanding Sleep01:11

Understanding Sleep

1.9K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.9K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

891
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
891
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

2.6K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
2.6K
Forgetting01:21

Forgetting

505
Forgetting is an intrinsic aspect of human memory, characterized by the gradual loss or inaccessibility of information over time. Hermann Ebbinghaus, a pioneering psychologist, extensively studied this phenomenon and formulated the forgetting curve. This curve illustrates that memory loss occurs rapidly immediately after learning and then decelerates over time. Several mechanisms contribute to forgetting, including encoding failure, storage decay, retrieval failure, and interference.
Encoding...
505

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Proximity labelling of D1-like dopamine receptors reveals distinct cellular environments and uncovers trafficking proteins that regulate DA mediated behaviors in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026
Same author

Pharmacological rescue of mitochondrial dysfunction, neurite degeneration, and premature death of ALS and AD iPSC-derived neurons.

bioRxiv : the preprint server for biology·2026
Same author

Dopamine neuron specific RNA-sequencing reveals Neprilysin 1 acts downstream of the cohesin complex to suppress learning.

Communications biology·2026
Same author

Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling.

bioRxiv : the preprint server for biology·2026
Same author

Anesthesia-triggered dopaminergic bursts actively induce forgetting: a paradigm shift in understanding cold-shock amnesia.

bioRxiv : the preprint server for biology·2025
Same author

Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia activity.

bioRxiv : the preprint server for biology·2025

関連する実験動画

Updated: Apr 10, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.7K

睡眠は,ドーパミンの神経媒介による忘却を阻害することによって,記憶を促進します.

Jacob A Berry1, Isaac Cervantes-Sandoval1, Molee Chakraborty1

  • 1Department of Neuroscience, Scripps Research Institute Florida, Jupiter, FL 33458, USA.

Cell
|June 16, 2015
PubMed
まとめ

睡眠は,行動状態によって調節されるプロセスであるドーパミン神経細胞の活動を減少させることで,記憶保持を強化します. この発見は,睡眠と忘却に関する心理学と神経科学の観点を統合しています.

科学分野:

  • 神経科学は神経科学である.
  • スリープ・リサーチ 睡眠研究
  • メモリコンソリデーション メモリ整合

背景:

  • 心理学では,睡眠が遡及的干渉を防止すると示唆しているが,神経科学では睡眠が記憶の統合を強化すると示唆している.
  • ドロソフィラのドーパミンニューロン活動は,嗅覚記憶の忘却を調節する.

研究 の 目的:

  • 行動状態依存記憶調節におけるドーパミナージック活動の役割を調査する.
  • 睡眠と忘却に関する心理学と神経科学の発見を統合する.

主な方法:

  • ドロソフィラのドーパミン作用のモニタリングは,異なる行動状態 (活動と休息) で行われる.
  • ガボクサドールを用いて睡眠駆動を調節し,睡眠回路の遺伝子刺激.
  • 睡眠操作と覚醒誘導後の記憶保持の評価.

主要な成果:

  • ドーパミン活性性は,運動運動活動とともに増加し,休息すると減少します.
  • 睡眠意欲が高くなると,ドーパミナージック活性が低下し,記憶保持が強化される.
  • 興奮が増加すると,ドーパミナージック活性が上昇し,忘却が加速されます.

結論:

さらに関連する動画

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

4.4K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K

関連する実験動画

Last Updated: Apr 10, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.7K
The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

4.4K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K
  • 忘却は,ドーパミナージック可塑性の行動状態調節によって調節されます.
  • 発見は,記憶における睡眠の役割に関する心理学と神経科学の理論を調和させています.
  • ドーパミンニューロン活動は,行動状態と記憶の持続性を結びつける重要なメカニズムとして機能します.