人間の心臓における細胞生成と循環のダイナミクス
Olaf Bergmann1, Sofia Zdunek1, Anastasia Felker1
1Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
Cell
|June 16, 2015
まとめ
人間の心とは,人間の心です.
科学分野:
- 心血管生物学 心血管生物学
- 細胞ダイナミクス 細胞ダイナミクス
- 人間の生理学 人間生理学
背景:
- ヒトの生理学的心臓の成長と維持に細胞生成の貢献は,確立することが困難でした.
- 以前の研究では,成人ヒトの心臓における細胞周回に関する議論の余地のある結果が得られた.
研究 の 目的:
- 人間の心臓の心筋細胞,内皮細胞,中皮細胞の寿命細胞動態を決定する.
- ヒトの生涯にわたる細胞の生成と転用に関する包括的なモデルを確立する.
主な方法:
- 核爆弾実験で得られた炭素14 (14C) 年代測定を用いて,細胞の増殖と回転を定量化しました.
- ヒトの様々な年齢層における心筋組織における細胞集団を分析した.
- 細胞生成率と生涯にわたる再生をモデル化するための統合データ.
主要な成果:
- 完全な心筋細胞群は,生前形成され,生涯にわたって安定しています.
- 内皮細胞と中皮細胞の数は,出生から成人期まで大幅に増加します.
- 内皮細胞は生涯にわたって高回転率 (>年間15%) を表しますが,メゼンキマ細胞は限られた更新率 (成人期に年間<4%) を表しています.
- 心筋細胞の交換は,幼児期で最も高い (成人期には年間1%以下).
結論:
- 人間の心臓の成長は主に内皮細胞と中皮細胞の増加によって引き起こされ,心筋細胞の増殖によって引き起こされない.
- 内皮細胞は,生涯にわたって継続的に更新され,動的な心血管系を示唆しています.
- この研究は,人間の心臓における細胞の転移に関する定量的なモデルを提供し,長年にわたる論争を解決している.
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