勃起不全および悪性メラノーマのリスクに対するフォスフォディエステラゼ5型阻害剤の使用
Stacy Loeb1, Yasin Folkvaljon2, Mats Lambe3
1Department of Urology, Population Health, and Laura and Isaac Perlmutter Cancer Center, New York University, New York.
JAMA
|June 24, 2015
まとめ
勃起不全の治療に使用されるフォスフォディエステラゼ5型 (PDE5) 阻害剤は,男性における悪性メラノーマのリスクのわずかな増加と関連していました. この関連性は,単一の処方箋で最も強く,因果関係を疑問視した.
科学分野:
- 腫瘍学 腫瘍学
- 薬理学 薬理学とは
- エピデミオロジー エピデミオロジー
背景:
- リン酸エステラゼ5型 (PDE5) 阻害剤は,勃起不全を治療する口服薬です.
- PDE5経路は悪性メラノーマ発症に関与している.
- 以前の報告では,シルデナフィル使用者のメラノーマのリスクが増加していることが示唆されています.
研究 の 目的:
- PDE5阻害剤の使用とメラノーマのリスクとの関連を調査する.
- 特定のPDE5阻害剤,処方箋数,およびメラノーマのステージに基づいてリスクを分析する.
主な方法:
- スウェーデンでは,全国規模で,人口をベースに,ネスティングした症例対照研究が行われました.
- データはスウェーデンの健康登録簿から得られたもので,4065例のメラノーマ (2006年−2012年) と出生年によってマッチした対照群を含む.
- 暴露は,シルデナフィル,ヴァルデナフィル,またはタダラフィルの処方箋によって定義されました.
主要な成果:
- PDE5阻害剤を使用した男性は,メラノーマのリスクが増加したことを示しました (OR, 1.21).
- 最も高いリスクは,単一の処方箋 (OR,1.32) と関連しており,複数の処方箋では有意な増加はありませんでした.
- PDE5阻害剤の使用は,初期段階のメラノーマ (ステージ0およびI) と基礎細胞癌と関連していました.
結論:
- 男性におけるPDE5阻害剤の使用は,悪性メラノーマのリスクのわずかな,統計的に有意な増加と関連しています.
- 観察されたパターン,特に複数の処方箋との関連性の欠如は,因果関係に関する疑問を提起します.
- PDE5阻害剤とメラノーマとの関係を明らかにするためにさらなる研究が必要である.
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