医療用カンナビノイド:体系的なレビューとメタ解析
Penny F Whiting1, Robert F Wolff2, Sohan Deshpande2
1School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom2The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West at University Hospitals, Bristol NHS Foundation Trust.
JAMA
|June 24, 2015
まとめ
カンナビノイドは慢性疼痛と性の緩和に適度な証拠を示し,化学療法による吐き気などの他の状態に対する証拠は低い. 有害事象の増加が認められた.
科学分野:
- 医学研究 医学研究
- 薬理学 薬理学とは
- システマティック・レビューとメタ分析
背景:
- 大麻とカンナビノイド薬は,医療目的でますます使用されています.
- しかし,特定の健康状態に対する有効性は不明である.
研究 の 目的:
- カナビノイド使用の利点と有害事象を体系的にレビューする.
- さまざまな医療用指標におけるカンナビノイドの証拠を評価する.
主な方法:
- 28のデータベースから79のランダム化臨床試験 (6462人の参加者) の体系的なレビューを実施しました.
- 化学療法による吐き気/嘔吐,食欲刺激,慢性疼痛,性,その他の症状に焦点を当てた試験が含まれています.
- バイアスのコクランリスクツールを用いて研究の質を評価し,可能な限りメタ分析を行った.
主要な成果:
- 中程度の証拠は,慢性的な痛みと性に対するカンナビノイドをサポートしています.
- 化学療法による吐き気/嘔吐,HIV/AIDSによる食欲刺激,睡眠障害,トゥレット症候群に対する効果は少ない.
- カンナビノイドは,めまい,口乾燥,疲労などの短期的な有害事象の発生率が高いと関連していました.
結論:
- カンナビノイドは,慢性疼痛と性に対する有効性を示しています.
- 他の徴候に関する証拠は限られているが,潜在的な利益を示唆している.
- 副作用のリスクの増加は,カンナビノイド療法について慎重に検討する必要がある.
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