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コア・スプライソームは,非正規のATM信号のターゲットとエフェクタとして機能する

Maria Tresini1, Daniël O Warmerdam2, Petros Kolovos3

  • 1Department of Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands.

Nature
|June 25, 2015
PubMed
まとめ

DNAダメージ反応には,スプライソームの異位とRループの形成があり,ATMキナーゼを活性化します. このフィードバックループは,DNA損傷後の組織ホメオスタシスの維持に不可欠な代替スプライシングを強化します.

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