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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
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脳の微小出血は脳卒中のリスクの増加と関連している: ロッテルダム研究
Saloua Akoudad1, Marileen L P Portegies1, Peter J Koudstaal1
1From Departments of Epidemiology (S.A., M.L.P.P., A.H., M.A.I., M.W.V.), Radiology (S.A., A.v.d.L., M.A.I., M.W.V.), and Neurology (S.A., M.L.P.P., P.J.K., M.A.I.), Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Circulation
|July 4, 2015
まとめ
MRIで検出された脳の微小出血は,一般人口の脳卒中リスクの高さに関連しています. これらの発見は,マイクロブレイドが脳血管疾患の悪化を示し,脳卒中の発生に先行する可能性があることを示唆しています.
科学分野:
- 神経学 神経学とは
- 放射線学 放射線学
- エピデミオロジー エピデミオロジー
背景:
- 脳の微小出血は,脳血管疾患において一般的であり,脳卒中の再発を予測します.
- 健康な高齢者におけるそれらの臨床的意義は不明である.
研究 の 目的:
- 一般集団における脳内微小出血とインシデント脳卒中リスクとの関連性を調査する.
- 微小出血の特徴 (存在,数,位置) が脳卒中リスクを変化させるかどうかを判断する.
主な方法:
- 4759人の参加者 (年齢 ≥45歳) を対象とした人口ベースのロッテルダム研究.
- 脳のMRIは,ベースラインで微小出血を評価し,参加者は脳卒中 (2005年−2013年) について追跡調査を行った.
- 混同因子に調整されたコックス比例危険性モデル.
主要な成果:
- 微小出血の罹患率は18.7%であり,追跡期間中に93件の脳卒中が発生しました.
- 微小出血の存在は,すべての脳卒中のリスク1.93倍増加と関連しています.
- 側頭葉の微小出血は脳内出血のリスクを5.27倍に増加させ,他の部位では不全性脳卒中と出血性脳卒中の両方のリスクを増加させた.
結論:
- MRIにおける脳微小出血は,一般人における脳卒中リスクの増加の独立したマーカーである.
- マイクロブレイドは,脳血管病理の進行を代表し,脳卒中の前兆として機能する可能性があります.
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