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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Prevention02:59

Cancer Prevention

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3.1K
Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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関連する実験動画

Updated: Apr 7, 2026

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
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Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

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AIMing 2 がんを抑制する

Leah M Rommereim1, Naeha Subramanian1

  • 1Institute for Systems Biology, Seattle, WA 98101, USA.

Cell
|July 4, 2015
PubMed
まとめ

炎症性AIM2センサは,微生物と幹細胞を調節することによって,腸の健康を維持するために不可欠です. この発見は,先天的免疫を通して結腸直腸がんから身を守るための新しい洞察を提供します.

科学分野:

  • 免疫学 免疫学とは
  • 胃腸内科 胃腸内科
  • 微生物学 微生物学とは

背景:

  • 腸内微生物群と先天的な免疫は,健康にとって不可欠です.
  • 調節障害は,結腸直腸がんのような複雑な疾患に寄与する.

研究 の 目的:

  • 腸内本来のセンサーAIM2が腸内ホメオスタシスに果たす役割を調査する.
  • 結腸直腸がんから保護するAIM2の機能を理解する.

主な方法:

  • 微生物集団のAIM2の調節に関する分析.
  • 腸の幹細胞機能に対するAIM2の影響の評価.
  • 大腸がんの発症におけるAIM2の役割の評価.

主要な成果:

  • AIM2 (Absent in Melanoma 2) は,腸内の微生物と幹細胞のホメオスタシスの両方を調節することが判明しました.
  • AIM2によるこの調節は,結腸直腸がんの発症を予防する.

結論:

  • AIM2は,腸内の微生物と幹細胞のバランスを結びつける重要な細胞内センサーです.
  • AIM2経路をターゲットにすることで,結腸直腸がんの予防と治療のための新しい戦略を提供することができます.

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Last Updated: Apr 7, 2026

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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

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