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Updated: Apr 7, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

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KRAS変異性がんにおけるChk1-およびMK2阻害剤の相乗相互作用

Felix Dietlein1, Bastian Kalb1, Mladen Jokic1

  • 1Department I of Internal Medicine, University Hospital Cologne, Weyertal 115B, 50931 Cologne, Germany; CECAD, University of Cologne, Weyertal 115B, 50931 Cologne, Germany.

Cell
|July 4, 2015
PubMed
まとめ

CHK1およびMK2阻害剤を併用してKRAS変異がんをターゲットにすることは有望である. この戦略は,がん細胞死を誘発し,KRASおよびBRAF駆動腫瘍に対する潜在的な新しい治療法を提供します.

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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

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