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Updated: Apr 7, 2026

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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栄養素としての細胞外タンパク質の利用は,mTORC1によって抑制される

Wilhelm Palm1, Youngkyu Park2, Kevin Wright2

  • 1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|July 7, 2015
PubMed
まとめ

哺乳類の細胞は,マクロピノサイトーシスを利用して,細胞外タンパク質から必須アミノ酸を得ることができます. mTORC1を阻害すると,細胞がこの栄養源に依存するときにタンパク質の分解を促すことで細胞増殖が促進されます.

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A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation09:37

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