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Updated: Apr 7, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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GPCRsによるGα活性化のための汎用アロステリックメカニズム

Tilman Flock1, Charles N J Ravarani1, Dawei Sun2,3

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Nature
|July 7, 2015
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) は,保存されたアロステリックメカニズムを通じてGタンパク質を活性化します. この保存されたGタンパク質活性化メカニズムは,信号特異性を維持しながら,GPCRの急速な多様化を可能にしました.

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