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Updated: Apr 7, 2026

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale

Published on: March 14, 2019

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コファクター媒介型コンフォーマーションダイナミクスは,アロステリック経路経由でEscherichia coliジヒドロフォラート還元酵素から製品の放出を促進します

David Oyen1, R Bryn Fenwick1, Robyn L Stanfield1

  • 1Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|July 7, 2015
PubMed
まとめ

ディヒドロフォラート還元酵素 (DHFR) のタンパク質ダイナミクスは,触媒作用に影響します. この研究は,2つの製品放出経路を明らかにし,そのバランスを変化させ,酵素活性に影響する突然変異がある.

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