心臓代謝多病症と死亡率の関連性
, Emanuele Di Angelantonio1, Stephen Kaptoge1
1University of Cambridge, Cambridge, England.
JAMA
|July 8, 2015
まとめ
心臓代謝多発症は,平均寿命を大幅に短縮する. 糖尿病,脳卒中,心筋梗塞 (MI) のような2つの状態を持つことは,平均寿命を12年短縮し,3つとも15年短縮します.
科学分野:
- 心血管疾患の疫学について
- 公衆衛生に関する研究.
- 長寿研究とは,長寿に関する研究です.
背景:
- 心臓代謝性多発性疾患の流行が増加していることは,公衆衛生上の大きな課題となっています.
- 複数の心代謝疾患が平均寿命に与える影響を理解することは,予防戦略にとって極めて重要です.
研究 の 目的:
- 心臓代謝性多病症に関連した平均寿命の縮小を定量化する.
- 糖尿病,脳卒中,心筋梗塞 (MI) の組み合わせに関連した死亡リスクを分析する.
主な方法:
- Emerging Risk Factors Collaboration (ほぼ70万人の参加者) とUK Biobank (50万人の参加者) の個人参加者データを活用した.
- 心臓代謝疾患のある人やそれのない人の年齢と性別に調整された死亡率と危険比率 (HRs) を計算した.
- 推定累積生存率は,HRを米国の年齢別死亡率に適用することによって推定される.
主要な成果:
- 60歳で2つの心臓代謝疾患 (糖尿病,脳卒中,心筋梗塞) のいずれか1つを患っていたと,寿命が12年短縮されたと関連付けられました.
- 3つの疾患 (糖尿病,脳卒中,心筋梗塞) をすべて患っている人は,60歳で寿命が15年短縮された.
- 死亡リスクは,追加された状態ごとに倍数的に増加し,すべての原因による死亡率のHRは,参照グループと比較して1.9から6.9の範囲であった.
結論:
- 心臓代謝多発症は,平均寿命を大幅に短縮する.
- 糖尿病,脳卒中,心筋梗塞が死亡リスクに及ぼす影響は,多重的であり,長寿を大幅に減少させる.
- 公衆衛生の介入は,これらの状態の予防と管理に焦点を当てて,寿命への影響を軽減すべきである.
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