女性ホルモン要因とリンチ症候群における子宮内膜がんのリスク
Seyedeh Ghazaleh Dashti1, Rowena Chau1, Driss Ait Ouakrim1
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
JAMA
|July 8, 2015
まとめ
リンチ症候群の女性の場合,先月経の遅延,均等性,ホルモン避妊薬の使用などの要因は,子宮内膜がんのリスクの低下と関連しています. これらのホルモンの影響は,一般の集団で見られるものを反映しています.
科学分野:
- 婦人科 婦人科について
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
背景:
- リンチ症候群の女性の子宮内膜がんリスク軽減戦略は,子宮内切除を除いて,十分に確立されていません.
- 不一致修復遺伝子変異によって引き起こされるリンチ症候群は,子宮内膜がんを含む癌のリスクを大幅に増加させます.
研究 の 目的:
- リンチ症候群の女性において,様々なホルモン要因と子宮内膜がんを発症するリスクとの関係を調べる.
主な方法:
- 大腸がんファミリーレジストリからの不一致修復遺伝子変異を有する1128人の女性を対象とした遡及的なコホート研究.
- 収集されたデータには,初潮の年齢,均等性,出生年齢および更年期,ホルモン避妊薬の使用,および更年期後のホルモン使用が含まれています.
- 体重付きコホート分析は子宮内膜がんの発生率を評価するために使用されました.
主要な成果:
- 133人の女性で子宮内膜がんが診断されました.
- 初潮の遅い年齢 (≥13歳),均等性,およびホルモン避妊薬の使用期間 (≥1年) の長さは,子宮内膜がんのリスクの統計的に有意な減少と関連していました.
- 子宮内膜がんのリスクと最初の/最後の生児の年齢,更年期期の年齢,または更年期後のホルモン使用との間に有意な関連性が見つかりませんでした.
結論:
- 特定の内在的および外在的ホルモン要因は,リンチ症候群の女性の子宮内膜がんのリスク低下と関連しています.
- 観察されたホルモン関連は,一般の集団におけるものと比較できます.
- これらの発見は,リンチ症候群の女性は,子宮内膜がんのリスクに対するホルモンの影響に関して,一般の人々と同様にカウンセリングを受けることができることを示唆しています.
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