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Updated: Apr 7, 2026

Author Spotlight: Fluorescence-Based Quantification of Mitochondrial Membrane Potential and Superoxide Levels Using Live Imaging in HeLa Cells
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フォスフォウビキチン誘発のPARKIN活性化のメカニズム

Tobias Wauer1, Michal Simicek1, Alexander Schubert1

  • 1Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Nature
|July 11, 2015
PubMed
まとめ

リン酸化ユビキチンに結合したPARKINの結晶構造は,変異がパーキンソン病を引き起こす方法を明らかにします. この発見は,PARKINの活性化を説明し,この疾患の新たな治療目標を示唆しています.

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