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Updated: Apr 6, 2026

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors

Published on: September 10, 2013

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ホルモン-デンドリマー結合体のリガンドアクセシビリティとバイオアクティビティは,pHとpH履歴に依存する

Sung Hoon Kim, Zeynep Madak-Erdogan, Sung Chul Bae1

  • 1§IBS Center for Soft and Living Matter and UNIST, Ulsan 689-798, South Korea.

Journal of the American Chemical Society
|July 18, 2015
PubMed
まとめ

エストロゲン-デンドリマー結合体は,リガンドが閉じ込められるため,pHが低下すると不可逆的に生物活性を失います. このpH依存の活性喪失は,ポリアミドアミン (PAMAM) デンドリマーを用いた新しい薬剤投与システムの設計に不可欠である.

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