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Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

7.0K

Sirt7は,変形成長因子βシグナル伝達経路を維持することによって,心筋組織修復に貢献する

Satoshi Araki1, Yasuhiro Izumiya2, Taku Rokutanda1

  • 1From Departments of Cardiovascular Medicine (S.A., Y.I., T.R., S.H., Y.K., Y.O., H.O.) and Medical Biochemistry (T.S., T.Y., K.Y.), Graduate School of Medical Sciences, Kumamoto University, Japan; Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany (A.I., T.B., E.B.); Department of Cardiovascular Clinical and Translational Research, Kumamoto University Hospital, Japan (O.Y.); and Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Japan (N.K., M.K.).

Circulation
|July 24, 2015
PubMed
まとめ

シルトゥイン7 (Sirt7) は心臓血管組織修復に不可欠です. Sirt7の喪失は傷の治癒を阻害し,線維症と自閉症に影響することで心臓破裂のリスクを高めます.

キーワード:
オートファジーフィブロブラスト成長因子βを変換する受容体シルトゥイン傷が治る

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