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Updated: Apr 6, 2026

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
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人間 の 微生物 人間 の 微生物 群 の 小さな 分子

Mohamed S Donia1, Michael A Fischbach2

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. donia@princeton.edu fischbach@fischbachgroup.org.

Science (New York, N.Y.)
|July 25, 2015
PubMed
まとめ

ヒトの腸内微生物は 免疫調節のような 生物学的活動を持つ多数の小さな分子を 生成します 将来の技術により これらの重要な微生物群に由来する化合物の発見と理解が向上します

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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
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