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関連する概念動画

Chirality02:25

Chirality

32.5K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
32.5K
Prochirality02:05

Prochirality

5.4K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
5.4K
Chirality in Nature02:30

Chirality in Nature

18.0K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
18.0K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

16.5K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
16.5K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

11.9K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
11.9K
Conjugated Proteins02:50

Conjugated Proteins

29.8K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
29.8K

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Updated: Apr 6, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
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Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

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チラルの結合サンゴ

Melissa Ball1, Brandon Fowler1, Panpan Li2,1

  • 1†Department of Chemistry, Columbia University, New York, New York 10027, United States.

Journal of the American Chemical Society
|July 31, 2015
PubMed
まとめ
この要約は機械生成です。

研究者らは,電子ドナー (ビチオフェン) と受容体 (ペリレンダイミド) を交互に配合した新型のストレントマクロサイクルを開発した. これらの分子には独特のステレオアイソマーと,相互変換のための"分子内逆転"メカニズムがあります.

さらに関連する動画

A Micropatterning Assay for Measuring Cell Chirality
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A Micropatterning Assay for Measuring Cell Chirality

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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

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関連する実験動画

Last Updated: Apr 6, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

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A Micropatterning Assay for Measuring Cell Chirality
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A Micropatterning Assay for Measuring Cell Chirality

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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
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Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

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科学分野:

  • 有機化学
  • 超分子化学
  • 材料科学

背景:

  • 結合されたマクロサイクルは,超分子化学において極めて重要です.
  • 特定の空洞と電子特性を備えたマクロサイクルを設計することは依然として課題です.

研究 の 目的:

  • 緊張したコンジュガートマクロサイクルに新しいデザインモチーフを導入する.
  • 電子ドナーと受容子の単位を交代してマクロサイクルを作成します.
  • これらの新しいマクロサイクルの立体化学とダイナミクスを調査する.

主な方法:

  • ビチオフェン (ドナー) とペリレンダイミド派生体 (受容体) を用いたA-B-A-Bパターンのマクロサイクル合成.
  • ステレオ同位体分離のためのキラル高性能液体染色法 (HPLC).
  • スペクトル解析と密度関数理論 (DFT) の計算.

主要な成果:

  • 硫黄原子とペリレンダイミド π 面で覆われた持続的な円形の空洞を持つマクロサイクルの形成.
  • 3つのステレオアイソマーがうまく分離したキラルとアキラル形態の存在.
  • ステレオアイソメアの相互変換のための"分子内サマーサルト"メカニズムの観察.
  • 広い可視吸収スペクトルとビチオフェンからペリレンダイミドへの光誘導電子移転

結論:

  • 新しいデザインのモチーフは,複雑で,緊張した,結合されたマクロサイクルの構築を可能にします.
  • 特定された"分子内逆転"メカニズムは,マクロサイクルダイナミクスへの洞察を提供します.
  • これらのマクロサイクルは,分子内電子移転により興味深い光物理的特性を有しています.