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コンピュータ設計による人工金属酵素の触媒性能の改善

Tillmann Heinisch1, Michela Pellizzoni1, Marc Dürrenberger1

  • 1†Department of Chemistry, University of Basel, 4056 Basel, Switzerland.

Journal of the American Chemical Society
|July 31, 2015
PubMed
まとめ

計算上の設計により,非対称的還元における触媒活性とエナチオ選択性を改善するために,人工移転水酸化酵素 (ATHases) を最適化した. この改良された酵素設計により,重要な医薬品前駆体である (S) - サルソリジンの生産量が増加しました.

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