配偶 者 の 選択 に 関し て,娘 の 母親 に 対する 許容 度 が 重要 な もの
Jeffrey R Singer1, Casey T Weaver1
1Department of Pathology, University of Birmingham at Alabama, Birmingham, AL 35294 USA.
Cell
|August 2, 2015
まとめ
遺伝しない抗原に対する免疫耐性を生み出す. この非遺伝的遺伝は,配偶者と抗原を共有するメスの胎児の損失を減らすことで生殖能力を向上させます.
科学分野:
- 生殖免疫学
- 遺伝学
- 発達生物学
背景:
- メンデルの遺伝学では DNAによる遺伝が説明されています
- 生殖能力における非遺伝的要因の役割はますます認識されています.
研究 の 目的:
- 子孫の免疫耐性に対する母親の微化学性の影響を調査する.
- 遺伝しない母性抗原が 生殖の成功に 影響するかどうかを判断する.
主な方法:
- 子孫における母性微化学の分析
- 遺伝しない母性抗原に対する免疫耐性の評価
- 配偶者間の抗原共有に関連した胎児の消耗の評価.
主要な成果:
- 遺伝しない母性抗原に対する安定した免疫耐性を確立する.
- これらの抗原を配偶者と共有する雌の子孫は 胎児の衰えを減少させる.
- 非遺伝的情報の垂直伝達は 生殖能力において重要な役割を果たします
結論:
- 母親の微化学反応は,免疫耐性を世代を超えて伝達するメカニズムです.
- マイクロキメリズムによる非遺伝的遺伝は,生殖能力を高めることができます.
- この発見は 遺伝と適性に関する 純粋にDNAを中心とした見解に 異議を唱えます
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