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Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
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Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

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ミスターゲットのミトコンドリアタンパク質は,細胞溶液内のプロテオスタティック反応を活性化させる

Lidia Wrobel1, Ulrike Topf1, Piotr Bragoszewski1

  • 1International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland.

Nature
|August 7, 2015
PubMed
まとめ

ミトコンドリアのタンパク質の輸入の欠陥は 細胞の保護反応を誘発する タンパク質を誤って標的にすることで活性化されるこの展開タンパク質反応 (UPRam) は,タンパク質合成を阻害し,誤って位置づけられたタンパク質をクリアするためにプロテアソームを活性化します.

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