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Updated: Jan 18, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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腫瘍性PIK3CAによるマルチポテンシーの再活性化により,乳腺腫瘍の異質性が生じます

Alexandra Van Keymeulen1, May Yin Lee1, Marielle Ousset1

  • 1Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium.

Nature
|August 13, 2015
PubMed
まとめ

この研究は,PIK3CA遺伝子の変異が正常な乳がん細胞を再プログラムし,様々な腫瘍型を生み出し,乳がんの異質性を引き起こすことを明らかにしています. この細胞の起源を理解することは 新しい治療戦略の開発の鍵です

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