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ハイブリッド 周辺 肝 細胞 は 損傷 し た 肝臓 を 再生 し て 癌 を 生み出す こと は ない
Joan Font-Burgada1, Shabnam Shalapour1, Suvasini Ramaswamy2
1Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Cell
|August 16, 2015
まとめ
ハイブリッド肝細胞として知られる特定のタイプの肝細胞は,損傷後の肝組織を再生できますが,肝がん (肝細胞がん) を引き起こしません. これらの細胞は 細胞ベースの治療の可能性を秘めています
科学分野:
- ヘパトロジー
- 再生医療
- 癌 生物学
背景:
- 肝細胞の補償増殖は肝臓の再生に不可欠ですが,肝細胞癌 (HCC) の発症を誘発することもできます.
- 肝細胞の補充とHCCの発症に責任のある特定の細胞タイプは,まだ十分に理解されていません.
研究 の 目的:
- 肝臓が慢性的に損傷した後に肝細胞を補充する細胞を特定する.
- 肝細胞がん (HCC) の発症におけるこれらの細胞の役割を調査する.
主な方法:
- ネズミのモデルで 遺伝的系統を追跡した
- 健康な肝臓の細胞群を分析し,慢性的に肝細胞を枯渇させる傷害を受けた.
- 特定された細胞が3つの異なるHCCモデルに与える貢献を調査した.
主要な成果:
- 肝臓の再生に責任を持つ,既にある周辺肝細胞群 (低 Sox9 を発現する) を特定した.
- これらの"ハイブリッド肝細胞"は,損傷後の肝臓の質量を回復するために広く増殖します.
- 高い再生能力にもかかわらず,ハイブリッド肝細胞は研究されたモデルでHCCの発生に寄与しませんでした.
結論:
- 周縁のハイブリッド肝細胞は腫瘍形成を促すことなく肝臓再生の重要な原動力です.
- これらの細胞は 組織修復のための 独特の経路を代表し 癌の発生を防ぎます
- ハイブリッド肝細胞は慢性肝疾患の治療用細胞源として有望である.
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