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Updated: Apr 5, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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代替 Wnt 信号は YAP/TAZ を活性化する

Hyun Woo Park1, Young Chul Kim2, Bo Yu3

  • 1Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Cell
|August 16, 2015
PubMed
まとめ

転写共同活性化剤YAPとTAZは,臓器のサイズと組織ホメオスタシスの主要な調節剤であり,その調節不良はヒトの癌に寄与する. YAP/TAZは 代替Wnt信号経路の 真の下流エフェクタとして発見されました Wnt5a/bとWnt3aは,正規のWnt/β-cateninシグナルから独立してYAP/TAZ活性化を誘導する. 機械的には,YAP/TAZの活性化とTEAD媒介による転写を促進するために,Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2からなる"代替 Wnt-YAP/TAZシグナル伝達軸"を図示する. YAP/TAZは,遺伝子発現,骨性分化,細胞移動,およびWnt/β-カテニンのシグナル伝達の抗作用を含む,代替 Wntシグナル伝達の生物学的機能を媒介する. YAP/TAZは代替 Wnt 信号の重要な仲介者として確立しています

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