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Updated: Apr 5, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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CRISPRのCTCFサイトの逆転により,ゲノムトポロジとエンハンス/プロモーター機能が変化する

Ya Guo1, Quan Xu1, Daniele Canzio2

  • 1Center for Comparative Biomedicine, MOE Key Laboratory of Systems Biomedicine, Institute of Systems Biomedicine, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University (SJTU), Shanghai 200240, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, SJTU, Shanghai 200240, China; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (MOE), Bio-X Center, School of Life Sciences and Biotechnology, SJTU, Shanghai 200240, China.

Cell
|August 16, 2015
PubMed
まとめ

CTCF結合部位 (CBS) の方向性は,哺乳類のゲノムでDNAループが形成される方法を決定する. この指向は3Dゲノム構造を制御することで 遺伝子発現に影響を与えます

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