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Updated: Apr 5, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

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HLAクラスI結合ペプチドに対する拡張O-GlcNAc

Fabio Marino1,2, Marshall Bern3, Geert P M Mommen1,2,4

  • 1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Journal of the American Chemical Society
|August 18, 2015
PubMed
まとめ

研究者らは,ヒト白血球抗原 (HLA) クラスIペプチドに予期せぬ糖化作用を発見した. HLAペプチドのこれらの拡張されたO-リンクされたN-アセチルグルコサミン (O-GlcNAc) 変異は,免疫監視の重要な標的である可能性があります.

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