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Updated: Apr 5, 2026

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

Published on: June 7, 2018

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構造的適応性 サイトクロームP450におけるヒスティジンヘム結合を促進する

John A McIntosh1, Thomas Heel1, Andrew R Buller1

  • 1Division of Chemistry and Chemical Engineering 210-41, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.

Journal of the American Chemical Society
|August 25, 2015
PubMed
まとめ

研究者は重要なシステイン残基をヒスティジンに変異させ,サイトクロームP450 (CYP) 酵素の活性部位を調査した. この構造の変化は,新しい触媒活動と酵素特性を明らかにし,将来の研究に役立てました.

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