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Updated: Apr 5, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
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AIDが誘発するDNA断裂の指向特有の結合は,抗体クラスの切り替えを促進する

Junchao Dong1, Rohit A Panchakshari1, Tingting Zhang1

  • 1Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Nature
|August 27, 2015
PubMed
まとめ

クラス・スイッチ・リコンビネーション (CSR) は,生産的な消去指向のためにプログラムされています. この研究は,免疫グロブリン重鎖遺伝子組織と活性化誘発のシチジンデアミナーゼによるDNA二重鎖の断裂を含む前例のないメカニズムを明らかにしています.

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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
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Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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