祖父母 の 食事 は 次 の 世代 の 体重 と 陰性 性 症 の 危険 に 影響 する か
Thomas Chambers1, Amanda Drake2, Richard Sharpe1
1MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Lancet (London, England)
|August 28, 2015
まとめ
祖父母の高脂肪食は 代々の代謝と生殖健康に 負の影響を及ぼします 肥満の流行の原因は これまで理解していたよりも 広い範囲に及ぶことが示唆されています
科学分野:
- エピジェネティクスと健康と病気の発達起源 (DOHaD)
- 代謝と生殖の健康について
背景:
- 世界保健機関 (WHO) は 予防 可能な 原因 を 特定 し て い ます.
- ダイエットや運動が 認められた要因であるが,新しい証拠は 親や祖父母の食事習慣も 役割を果たす可能性があることを示唆している.
- 高脂肪食 (HFD) モデルを使用して,世代間の健康への影響を調査した.
研究 の 目的:
- 祖父母の高脂肪食 (HFD) が次世代の代謝と生殖健康に与える影響を調査する.
- ダイエットに関連する世代間の健康効果の潜在的メカニズムを探求する.
主な方法:
- シュプラグ・ダウリー・ラットは14週間にわたってHFD (45%脂肪) または対照食事 (10%脂肪) を摂取した (F0世代).
- F0ネズミはF1の子孫を産むために繁殖され,F2の子孫を産むために繁殖する前にコントロールダイエットで維持された.
- F0,F1,F2世代で代謝および生殖パラメータを評価し,ANOVAおよび混合モデルを使用してデータを分析した.
主要な成果:
- HFDを受けたF0ネズミは体重増加と内臓肥満を示した.
- HFDの母親のF1の子と,HFDの父親のF1娘は体重が増加した.
- HFDの祖父のF2の雄の子は体重が増加し,内臓の脂肪,血のレプチン,およびルテイン化ホルモンとテストステロンの比率が変化しました.
- 母方の祖父がHFDを摂取したF2の子孫 (雄と雌) は,インスリン感受性の低下を示した.
結論:
- 祖父母のHFDは 性別や世代に固有の方法で 2つの次世代の代謝と生殖健康に大きく影響します
- この発見は 現在の肥満の流行が 現在認識されているより 複雑な病因を持つ可能性を示唆しています
- これらの世代を超えた効果の背後にある正確な因果メカニズムを明らかにするには,さらなる研究が必要です.
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