胎児の感染予防のための局所用軟化剤: 系統的レビュー
Jemma Cleminson1, William McGuire1
1University of York, York, UK.
Lancet (London, England)
|August 28, 2015
まとめ
局所用軟化剤は,早産児の侵入性感染症や死亡を防ぐことはできません. 低所得国における新生児の皮膚ケアのために,低コストの局所用オイルに関するさらなる研究が推奨されています.
科学分野:
- 新生児皮膚科
- 感染症予防
- 根拠に基づいた医療
背景:
- 胎児の皮膚の障壁は未成熟で 感染症のリスクが高まります
- 局所用軟化剤は皮膚の整体性を高め,感染症を予防する.
- 侵襲性感染症は早産児の死亡の主な原因です
研究 の 目的:
- 乳児における侵襲性感染症と死亡率の予防のための局所的軟化剤の使用に関する証拠を体系的に検討する.
主な方法:
- ランダム化制御試験の体系的レビュー
- 2809人の早産児を対象とした16件の試験を含む.
- 低所得国と高所得国のサブグループ分析
主要な成果:
- メタ解析では,軟化剤による感染率が高いことが示された (RR 1. 20).
- 死亡率や他の疾患に対する有意な影響は認められなかった.
- 低所得国における局所用オイルは感染や死亡率に 顕著な影響を及ぼさなかったが,体重と身長増加を改善した.
結論:
- 現時点のデータは,早産児の感染や死亡を予防する軟化剤の有力な証拠を欠いている.
- 低コストの局所用オイルのさらなる大規模な試験は,低所得環境における新生児のケアのために正当化されています.
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