多次元の喘息のエンドタイプ:横断的な臨床的,病理的,および免疫学的データのトポロジカルデータ分析
Timothy Hinks1, Xiaoying Zhou2, Karl Staples2
1Southampton NIHR Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, UK.
Lancet (London, England)
|August 28, 2015
まとめ
粘膜関連インヴァリアントT細胞 (MAIT) は,特に重症な喘息で減少しており,新しい欠乏症を示唆しています. Tヘルパー型17 (Th17) 細胞はヒトの喘息病原性において重要な役割を果たすようには見えません.
科学分野:
- 免疫学
- 呼吸器医学
- システム生物学
背景:
- 喘息の病原性と異質性は まだ十分に理解されていないため 研究の進展を妨げています
- ヒトの喘息におけるTヘルパー型17 (Th17) と粘膜関連インヴァリアントT細胞 (MAIT) の役割は調査が必要である.
- パーソナライズされた医療の進歩には 新しい多次元の喘息の内型を特定することが重要です
研究 の 目的:
- 喘息の呼吸道炎症におけるTh17とMAIT細胞の役割を調査する.
- 喘息の臨床的および免疫学的特徴の関連性を特徴づける.
- 先進的な分析技術を用いて新しい多次元喘息の内型を特定する.
主な方法:
- 喘息患者と健康な対照群を対象とした英国における横断的観察研究.
- 臨床,生理,免疫学的評価 血液,唾液,腸内組織生検,気管支柱洗浄を含む.
- フローサイトメトリ,マルチプレックス電気化学発光,ベイジアンネットワーク分析 (BNA),およびトポロジカルデータ分析 (TDA) が採用された.
主要な成果:
- Th17 細胞と γδ17 細胞は,重度の中性愛型を含む喘息との関連性を示さなかった.
- MAIT細胞の頻度は,健康な対照群と比較して,特に重症の場合,著しく低下しました.
- トポロジカルデータ分析では,重度の喘息でマスト細胞媒介体が増加した6つの新しい臨床病理学的クラスターが特定されました.
結論:
- Th17細胞はヒトの喘息において主要な病原性作用を持つようには見えません.
- 重度の喘息におけるMAIT細胞の新たな欠乏症が記述されている.
- トポロジカルデータ分析により,多次元の喘息のエンドタイプを特定する可能性があることが示され,さらなる検証が必要である.
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