GLP-1の分泌を増やし,グルコース耐性を改善し,健康なボランティアの食事の量を減らすことができますか? ランダム化,プラセボ対照,クロスオーバー試験
Claire L Meek1, Frank Reimann1, Adrian J Park2
1University of Cambridge, Cambridge, UK.
Lancet (London, England)
|August 28, 2015
まとめ
グルタミン補給は,健康なボランティアのグルカゴン型ペプチド1 (GLP- 1) の分泌とインスリン放出を増加させた. しかし,この効果は小さく,食事の大きさを増加させ,体重管理に臨床的に有用でないことを示唆しました.
科学分野:
- 代謝と内分泌学
- 胃腸の生理学
- 栄養学
背景:
- 肥満は世界的な健康問題で 治療費が高く 侵襲的な手術によって 管理されています
- 腹腔外科手術後の体重減少は,グルカゴン型ペプチド1 (GLP- 1) を含む腸内ホルモンの放出の増加と関連しています.
- グルタミンは潜在的GLP-1分泌剤であり,その効果に関する調査を促した.
研究 の 目的:
- 健康なボランティアでグルタミン補給が GLP-1 の放出を増加させるかどうかを判断する.
- グルタミンがグルコース耐性に与える影響を評価する.
- グルタミンが食事のサイズに与える影響を評価する
主な方法:
- 健康な成人を対象としたランダム化,ダブルブラインド,プラセボ対照のクロスオーバー研究.
- 単一の口服用6gの封装されたイレアル放出グルタミンまたはプラセボ.
- 主要エンドポイント:GLP-1濃度;二次エンドポイント:グルコース耐性および任意の食事量.
主要な成果:
- 90分後にGLP- 1濃度 (p=0. 004) とインスリン放出量 (p=0. 048) が有意に増加した.
- グルタミン摂取後の食事の大きさの顕著な増加が観察されました (p=0. 008).
- 安全性に関する有害事象は報告されていません.
結論:
- GLP-1の分泌とインスリン放出を刺激する.
- 観察された効果は控えめで,体重管理において臨床的に有意である可能性は低い.
- グルタミンは,GLP-1の無酸素効果を上回るインスリンによる食事の大きさを増加させた.
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