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Updated: Apr 4, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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フォスホイノシチド3キナーゼ関連の過剰成長: 細胞のフェノタイプと将来の治療選択肢

Victoria E R Parker1, Rachel G Knox1, Qifeng Zhang2

  • 1Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.

Lancet (London, England)
|August 28, 2015
PubMed
まとめ

線維細胞におけるPI3K- AKT経路を活性化し,増殖を促すことで,体内のPIK3CA変異が過剰成長障害を引き起こす. mTOR阻害剤は有望であり,p110α阻害剤は将来の治療法を提供する.

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