第1回精神病における大麻使用と治療抵抗性:自然言語処理の研究
Rashmi Patel1, Robin Wilson1, Richard Jackson2
1King's College London, Department of Psychosis Studies, Institute of Psychiatry, London, UK.
Lancet (London, England)
|August 28, 2015
まとめ
精神病の最初のエピソードで大麻の使用は一般的であり,より多くの入院と関連しています. これは部分的に必要な抗精神病薬の数が増加し,治療への反応が低下することを示唆しています.
科学分野:
- 精神科
- 臨床心理学
- 神経科学
背景:
- 大麻の使用は,最初のエピソード精神病 (FEP) を経験する個人に一般的です.
- 大麻の使用は,FEPの臨床結果の悪化と関連しています.
- FEPにおける抗精神病治療への大麻使用の影響は十分に理解されていません.
研究 の 目的:
- FEPにおける大麻使用と臨床結果の関連性を調査する.
- 大麻使用とFEPの悪い結果の関係に抗精神病薬の治療抵抗が媒介するかどうかを判断する.
主な方法:
- 南ロンドンでFEPを患った2026人の臨床記録から大麻の使用を特定するために自然言語処理を使用しました.
- 人口統計,診断,入院,抗精神病薬の処方に関するデータを収集した.
- 多変数回帰とメディエーション分析を用いて関連性を調べた.
主要な成果:
- FEPを持つ人の46.3%は,プレゼンテーション時に大麻を使用しました.
- 大麻の使用は,入院,強制入院,入院日数が5年以上に増加した.
- 抗精神病薬の使用量の増加は,これらの関連性を部分的に媒介し,治療抵抗性を示した.
結論:
- FEP患者の多くは大麻を使用しており,入院率が高くなります.
- 大麻の使用は従来の抗精神病治療の効果を低下させる可能性があります.
- この集団における大麻の使用を減らす戦略は,結果の改善に不可欠です.
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