鉄欠乏性貧血
Anthony Lopez1, Patrice Cacoub2, Iain C Macdougall3
1Department of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy, Lorraine University, Vandoeuvre-lès-Nancy, France.
Lancet (London, England)
|August 29, 2015
まとめ
鉄欠乏性貧血は 世界人口の3分の"に及ぶもので 母親と子供の健康に影響を及ぼします 最近の診断方法や 静脈注射鉄の治療は この広範囲に広がる病気の 安全で効果的な治療法を提供しています
科学分野:
- 血液学
- 公衆衛生
- 栄養学
背景:
- 鉄欠乏性貧血 (IDA) は,世界の人口の約3分の1に影響を及ぼす世界的な健康問題です.
- 小児 (0~5歳),妊婦,妊婦などの脆弱なグループに不均衡な影響を及ぼします.
- IDAは,慢性腎臓病,心不全,癌,炎症性腸疾患などの慢性疾患としばしば併発する.
研究 の 目的:
- 鉄欠乏性貧血の総合的な概要を提示する.
- 現在の診断方法,治療戦略,将来の研究方向について議論する.
主な方法:
- IDAの臨床表現,流行病学,および病理生理学のレビュー
- 血清フェリチンとトランスファーリン飽和度を含む様々なバイオマーカーの診断精度の評価
- 経口鉄,静脈内鉄,ヘプシジンベースの治療法を含む,現在および新興の治療法の評価.
主要な成果:
- 血清フェリチンとトランスファーリン飽和度などの高度な診断マーカーは,IDA診断の伝統的な赤血球指数よりも高い精度を提供します.
- 静脈内での鉄分配合は 鉄分を補うための安全で効果的な代替手段です
- ヘプシディンは,診断と治療の応用が可能な鉄の恒常性の重要な調節剤として浮上しています.
結論:
- 鉄欠乏性貧血は,多面的な管理戦略を必要とする重大な世界的な健康問題です.
- 先進的なバイオマーカーによる正確な診断と 現代の鉄製剤による効果的な治療は不可欠です
- ヘプシディンの役割に関するさらなる研究は,IDAのための新しい治療目標を解き明かすことができます.
関連する概念動画
01:27Disorders of Erythrocytes
2.9K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.9K
01:24Factors Affecting Erythropoiesis
7.5K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
7.5K
00:57The Periodic Table and Organismal Elements
205.8K
OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
205.8K
01:14Erythropoiesis
6.8K
Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
6.8K
01:24Microbes and Other Elemental Cycles
66
Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
66
01:28The Early Endosome: Endocytosis of Transferrin
5.2K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
5.2K