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Updated: Apr 4, 2026

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すべてのDDRは平等に作られるわけではない:非正規のDNA損傷反応

Rebecca C Burgess1, Tom Misteli2

  • 1National Cancer Institute, NIH, Bethesda, MD 20892, USA; Department of Biological Sciences, School of the Sciences, Stevenson University, Stevenson, MD 21153, USA.

Cell
|August 29, 2015
PubMed
まとめ

DNAダメージ応答 (DDR) は単一の経路ではなく,複数の非正規版を含む. これらの多様なDDRは 細胞の感知機構とモジュラーな組織に関する新しい洞察を提供します

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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