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Updated: Apr 4, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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DNA脱メチル化剤は,内生トランスクリプトによるウイルスミミクリを誘導することによって,結腸直腸がん細胞を標的とする

David Roulois1, Helen Loo Yau2, Rajat Singhania1

  • 1Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.

Cell
|August 29, 2015
PubMed
まとめ

低用量5-AZA-CdRは,ウイルスミミクリを誘発することによって,大腸がん発症細胞 (CIC) を標的とする. これはMDA5/MAVS/IRF7経路を活性化し,大腸がんの新たな治療戦略を提供します.

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