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Updated: Apr 4, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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endogenous retroviruses を含む dsRNA を通してがんにおけるインターフェロン反応を引き起こす

Katherine B Chiappinelli1, Pamela L Strissel2, Alexis Desrichard3

  • 1Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

Cell
|August 29, 2015
PubMed
まとめ

DNAメチルトランスフェラーゼ阻害剤 (DNMTis) は,がんの免疫信号をウイルス防御経路で活性化させます. これは卵巣がんにおけるアポトーシスを引き起こし メラノーマを免疫療法に敏感にし 新しい治療戦略を強調します

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