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Updated: Apr 4, 2026

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 7, 2019

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Phosphoenolpyruvateは,抗腫瘍T細胞反応の代謝チェックポイントである

Ping-Chih Ho1, Jessica Dauz Bihuniak2, Andrew N Macintyre3

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA.

Cell
|September 1, 2015
PubMed
まとめ

PEP (フォスフェノルピルバート) の生成を増やすことにより,腫瘍に浸透するT細胞の代謝再プログラムが,抗腫瘍免疫を強化する. T細胞におけるPCK1の過剰発現は,その効果因子機能を強化し,腫瘍の成長を抑制し,マウスの生存率を向上させる.

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