静電相互作用によるポリサカリドによるメタラサイクルとヘパリン検出のためのその応用
Li-Jun Chen1, Yuan-Yuan Ren1, Nai-Wei Wu1
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University , Shanghai 200062, PR China.
Journal of the American Chemical Society
|September 1, 2015
まとめ
この研究は,負の電荷を持つヘパリンで正電荷のオーガノプラチナ (II) メタラサイクルの最初の階層的な自己組み立てを示しています. このプロセスは絡み合ったネットワークを作り出し,ヘパリンの敏感で選択的な光検出を可能にします.
科学分野:
- 超分子化学
- 材料科学
- 協調化学
背景:
- 階層的な自己組み立ては 先進的な機能的な材料を作るのに 極めて重要です
- 分散金属サイクルは,超分子構造の多用途の支架として機能します.
- 電気静的相互作用は,電荷を持つ分子の自己組織化を促すことができます.
研究 の 目的:
- 静電相互作用によって誘発された離散金属サイクルの階層的な自己組み立ての最初の例を報告する.
- 自己組み立てのモニタリングのための集積誘発排出 (AIE) のアクティブ部分を導入する.
- ヘパリン検出のための敏感で選択的な光センサーを開発する.
主な方法:
- オーガノプラチナ (II) メタルサイクルの協調制御による自己組み立て.
- テトラフェニルエチレン (TPE) の導入
- ヘパリンを負の電荷の誘導体として使って 静電自体を組み立てる
- SEM,TEM,AFM,LSCMを用いた特徴付け
主要な成果:
- プラスの電荷を持つTPEメタラサイクルは,静電相互作用によって負の電荷を持つヘパリンで自己組み立てました.
- 絡み合った真珠のネックレスネットワークが形成され 顕微鏡で確認されました
- 光増強は成功した結合を示し",オン"反応をもたらした.
- このシステムはヘパリン検出に高い感度と選択性を示した.
結論:
- この研究は,対ポリアニオン誘発の金属サイクルの階層的自己組み立てのための新しい方法を示している.
- 開発されたTPE-metallacycleシステムは,ヘパリンのための効果的な光探知器として機能します.
- この研究はヘパリンを含むセンサーと結合アプリケーションの原理の証明を提供します.
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