アリルブロミドと三次アルキルハリドのニッケル触媒による還元結合
Xuan Wang1, Shulin Wang1, Weichao Xue1
1School of Materials Science and Engineering and ‡Department of Chemistry, Shanghai University , 99 Shang-Da Road, Shanghai 200444, China.
Journal of the American Chemical Society
|September 2, 2015
まとめ
新しいニッケル触媒反応は 単純な初期材料から 複雑な全炭素四次中心を効率的に生成します この方法は,幅広い機能群の許容性を提供し,複雑な有機分子を合成するのに価値があります.
科学分野:
- 有機化学
- カタリシス
- 合成方法論
背景:
- 三次アルキルハリドは,交互結合反応における挑戦的基板である.
- 複合的な有機分子の合成には 炭酸四分子の形成が不可欠です
- 以前の方法では 機能群の耐性が欠けていて 厳しい条件が求められます
研究 の 目的:
- 三次アルキルハリドの還元性アリレーションのための温和で効率的な方法を開発する.
- 炭素を全て含んだ分子を合成する
- 新しい触媒システムの範囲と限界を調査する.
主な方法:
- 三次アルキルハリドとアリルブロミドのニッケル触媒による還元結合.
- 反応条件の最適化,触媒,リガンド,添加物を含む.
- 基板の適用範囲と機能群の耐性を評価する.
主要な成果:
- 軽度のニッケル触媒による還元性アリレーションプロトコルが確立された.
- この反応は,中等から優れた収量を持つ全炭素四次中心を持つ製品を成功裏に生成した.
- 電子欠乏性アレンはイソメリゼーションを防ぐのに有効であることが示された.
結論:
- 開発されたNi-触媒方式は,すべて炭素の四次中心への簡単な経路を提供します.
- この反応は広範な適用性と高い機能群耐性を表している.
- ピリジンまたは4 - ((ディメチラミノ) ピリジンは反応を促進し,イミダゾリウム塩は効率を高めることができます.
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