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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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spliceosomeは,MYCが誘発するがんの治療上の脆弱性である

Tiffany Y-T Hsu1,2,3,4, Lukas M Simon4, Nicholas J Neill1,4

  • 1Verna &Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

Nature
|September 3, 2015
PubMed
まとめ

MYCの過剰発現は,RNA処理の重要なメカニズムであるスプリセソームをストレスにさらします. spliceosomeを阻害すると MYCが誘導する癌細胞を選択的に傷つけ,新しい治療標的を提示します.

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