Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

10.4K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.4K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

3.4K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.4K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.8K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.8K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

42.4K
Overview
42.4K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

13.9K
13.9K
Overview of DNA Repair02:25

Overview of DNA Repair

35.3K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
35.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Mutations and structural variants arising during double-strand break repair.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Learning about break-induced replication from bacteriophages.

Nature reviews. Molecular cell biology·2025
Same author

Arp2/3 and type-I myosins control chromosome mobility and end-resection at double-strand breaks in S. cerevisiae.

Nature communications·2025
Same author

The Mediator Kinase Module regulates cell cycle re-entry and transcriptional responses following DNA damage.

bioRxiv : the preprint server for biology·2025
Same author

Mutations and structural variants arising during double-strand break repair.

bioRxiv : the preprint server for biology·2025
Same author

Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint.

eLife·2024

関連する実験動画

Updated: Apr 4, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

4.2K

DNA 損傷反応の解読

James E Haber1

  • 1Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA.

Cell
|September 12, 2015
PubMed
まとめ
この要約は機械生成です。

エヴリン・ウィトキンとスティーブン・エルレッジは DNA損傷反応に関する画期的な研究で ラスカー賞を受賞しました 40年以上の研究で 細胞がDNAを修復する仕組みが 明らかになりました

さらに関連する動画

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
08:31

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy

Published on: June 8, 2018

9.8K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.4K

関連する実験動画

Last Updated: Apr 4, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

4.2K
Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy
08:31

Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy

Published on: June 8, 2018

9.8K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.4K

科学分野:

  • 分子生物学
  • 遺伝学
  • 細胞生物学

背景:

  • DNAダメージ応答 (DDR) は,ゲノムの完全性を維持するために不可欠です.
  • DDRを理解することは 癌の発生と老化を 理解するために不可欠です

研究 の 目的:

  • DNA損傷反応の研究の 先駆者を称えるために
  • 基本的な生物学的発見の重要性を強調する
  • 40年以上の科学的な貢献を 認めること

主な方法:

  • 何十年にもわたる 分子遺伝学の研究です
  • 重要な信号経路の解明
  • DNA修復メカニズムの特徴

主要な成果:

  • DNA損傷反応の重要な要素を特定した.
  • 細胞がDNAの損傷を 感知し信号を送る方法を明らかにしました
  • DNA修復の基礎知識を確立しました

結論:

  • ウィトキンとエルレッジの研究は DNA修復の分野を変革しました
  • 彼らの発見は 癌の研究と治療に 深い意味を持ちます
  • この賞は 基礎医学への 永続的な影響を表しています