Fn14を標的にすることで,がんによるカケキシアを予防し,生存期間を延長します
Amelia J Johnston1, Kate T Murphy2, Laura Jenkinson1
1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Cell
|September 12, 2015
まとめ
腫瘍死滅因子 (TNF) 超家族Fn14を抗体で標的にすることで,がんカシェキアと闘うことができます. このアプローチは 体重減少を抑制し 癌患者の炎症や筋肉の衰えを防ぐことで 寿命を延ばします
科学分野:
- 腫瘍学
- 免疫学
- 分子生物学
背景:
- 腫瘍死滅因子弱 (TWEAK) とその受容体Fn14は腫瘍で上調される.
- 腫瘍におけるFn14発現は,カケキシア,消耗症候群と関連しています.
研究 の 目的:
- 腫瘍誘発のカシェキアにおけるFn14信号伝達の役割を調査する.
- 抗Fn14抗体の治療の可能性を評価する.
主な方法:
- Fn14を発現する腫瘍を持つマウスモデルを使用した.
- Fn14を標的とした抗体投与
- 腫瘍の成長,体重減少,炎症,筋肉/脂肪の質を評価した.
- 野生型とFn14およびTWEAK欠乏した宿主におけるカシェキア発達の比較
主要な成果:
- 抗Fn14抗体は,腫瘍による体重減少を抑制することで,寿命を大幅に延長しました.
- 抗体は腫瘍に起因する炎症と脂肪と筋肉の減少を減少させた.
- 宿主ではなく腫瘍内のFn14信号が カケキシアを誘発します
結論:
- Fn14はがんカシェキアの病因において重要な役割を果たします.
- 抗Fn14抗体はカシェキアの有望な治療戦略です.
- Fn14を標的とした治療は,がん患者の生活の質と生存率を向上させる可能性があります.
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